1186, (2021). Fluigents i (patent pending) powerful pressure regulation algorithm is based on physical equations and self-learning routines that offer several benefits: By directly connecting a flow rate sensor, it is possible to monitor or control flow rate in real time. We offer modern microfluidic systems and components that enhance productivity. Combine it with a flow sensor to regulate directly in flow rate and inject precise amounts of volume in the system. No switch modules. Each module consists of a separate pressure channel and can be controlled independently. This allows the user to set a flow rate directly on the instrument display. Fluigent has developed a pressure-based technology that offers an integrated pressure supply and control (positive and negative pressure) in a light (< 170 g) and compact format (L*l*H = 7*5*4). Point of care devices needing a small footprint can have engineering challenges. Each module is a separate and independent pressure channel. mfcs ez fluigent Select modules you need and combine them together. Range available from -800 mbar for vacuum aspiration and up to 7 bar for pressure. The F-OEM makes use of the best combination of pneumatic, mechanical, and electrical elements associated with our new generation algorithm: Fluigent Direct Flow-rate Control (DFC) a self-learning algorithm that performs continuous adjustment over the algorithm parameters based on the actual response time. In this stand-alone configuration, the device allows for pressure or flow rate control and volume dispense making it ideal for benchtop use. When combined with a FLOW UNIT, one can control flow rate directly or deliver dispensed volumes as needed. Get full control of the setup in a single interface with plug and play capabilities available for all desktop OS, that allows control, monitoring, and automation feature. Configuration 3: 3 pressure modules 1 switch module. Focus on the experiment instead of looking at the PC. TheFlow EZis the most advanced system available forpressure-based flow control. This technology can be integrated in any custom project. The benefits of this technology are listed below. Connect the outlets of the P-SWITCH to independent reservoirs to perform independent injections. It provides a dual interface USB and RS232 for high versatility in the integration. Mixed pressure ranges can be connected to the same board (positive and negative pressures, and Push-Pull). Fluigent was the first company to solve this problem by introducing an innovative technology: pressure pumps. Fig 2: (left) Pneumatic schematic of a standard fluidic system using pressure to move fluids (right) Pneumatic schematic of Fluigent new technology. The platform allows one to choose the number of pressure modules (with different ranges, if required), valve modules, and flow sensors. What I like most is that you are independent of a computer and can directly control both positive and negative pressure.. Focus on the experiment instead of looking at the PC. The PRESSURE UNIT product line allow for the accurate measurement of pressure and vaccum within the range -1000 mbar to 7 bar. Available in two main product line, the LineUpTM series to lead evolutive, compact and adaptable operations and the MFCSTM series for customized and field proven experience. It can support a wide range of connections (Wi-Fi, BLE, IoT, USB, industrial bus), and embedded protocols. Prof. Jeroen Lammertyn, KU Leuven Belgium Biosensors group. These can easily be combined tomatch all application requirementsor reconfigure the system for a new experimental design. Excellent response time, pulseless and highly stable, Configurable with pressure and switch control modules, Standalone platform adapted to industrial uses. This technology combines electronic and pneumatic elements engineered together with well established Fluigent regulation algorithms and knowledge.

In the base configuration, the system controls pressure or vacuum, and the liquid flow is a function of system resistance, fluid viscosity, etc. ThePXmodules, are available in different pressure and vacuum ranges, to provide the optimum level of pressure control and resolution.

In the base configuration, the system controls pressure, and the liquid flow is a function of system resistance, fluid viscosity, etc. The use of pressure to handle fluids also provides a quick response time allowing for precise operations such as stop flow and accurate pressure/flow rate steps. The P-SWITCH allows to multiply the outlets of the system and the SWITCH EZ controls microfluidic valves. Complex pressure and flow distribution can be eliminated as the unit can be placed at the location where pressure, vacuum, or flow control is needed. TheLineUpP-SWITCHis a pneumatic valve controller. The applied pressure will automatically adjust to maintain the flow rate. The MFCSTM series and Flow EZTM with Fluigent valves can be used for automated cell perfusion as in the next video. The pressure automatically adjusts in the background to maintain the set flow rate. The Adapt is used to connect Flow EZ modules with different pressure ranges without the need of additional pressure sources. 5 that compares Fluigent solution with a standalone gas micropump. Output pressures, flow rate, and valves can be controlled by using OxyGEN Fluigent software, or our Software Development Kit (SDK) for custom software applications. Instead of looking at the PC, users can keep their eyes on the microscope, adjusting the control dial with one hand. The conception of a MFCS controller depends on your needs. A photonic technology institute tests a variety of lab-on-chip systems, the number of flow channels and the required pressures vary from one test to another. In addition, a microfluidic pressure pump can easily be integrated into a setup with the Software Development Kit (SDK).

See an example of applications using the MFCS series: Separation of parasites from human blood using deterministic lateral displacement, S. H. Holm, J. P. Beech, M. P. Barrett and J. O. Tegenfeldt, Lab Chip, vol.11, 2011. The PX Pressure-driven flow control simplifies fluid management even for multiple fluids, and reduces the time needed to add or remove channels. Point of care tests such as blood analysis, glucose monitoring, infectious disease testing, cholesterol testing, or cardiac markers are marketed1. Liquid flow rate ranges from a few nL/min to 5 mL/min. The applied pressure will automatically adjust to maintain the flow rate. When combined with theLINKmodule, the Flow EZcapabilities are extended by using Fluigent software to control the system, or to generate time based protocols and reccord data(OxyGEN software). The technology is powered by an embedded rechargeable battery to facilitate portability. Based on our industry leading experience, Fluigent has developed the patented QuadCore pneumatic system, the most advanced microfluidic pumping technology available. It provides flexibility without compromising performance (accuracy and response time). With a compact and modular design, the Flow EZ allows you to set and benefit quickly from the pressure-based flow control advantages for your experiments.

One can use large reservoirs and maintain continuous, pulseless flow for days without refilling. 0.1% thanks to our field-proven, patented FASTAB technology allowing optimal flow control with the robustness required in demanding industrial environments. This allows the user to set a flow rate directly on the instrument display. Graphically monitor in real-time the pressure measurement using the OxyGEN software. Pulse-free flow is critical for generating high quality and repeatable results. How to set the Flow EZ (power and pressure supply), Fluidic and pneumatic connection to the microfluidic setup, Extend the pressure system by adding modules, How to send and apply an order to pressurize a reservoir, How to disconnect a module to modify the pressure system, Add a flow sensor to control directly in flow rate, Switch the module OFF and stop the experiment, 67 avenue de Fontainebleau94 270 Le Kremlin-Bictre, LineUp Series, the new generation of microfluidic controllers, Comparison between peristaltic, syringe and pressure pumps for microfluidic applications, All-in-one pressure supply & pressure/flow control, Advantages of pressure-based microfluidics, Droplet and particle generation in microfluidics, 0,1% on the measured value (effective beyond 10% of the maximum pressure), Dry, oil-free gas, air, any non corrosive or non explosive gas, Aqueous solvent, oil, organic solent, biological sample, Control in real-time, protocol automation, data record and export. The Push-Pull allows for regulatation of pressure and vacuum down to -800 mbar and up to 1 bar from one single channel. It can be used without a PC or controlled with Fluigent Software Solutions to benefit from control in real-time, protocol automation, graphic displays and custom integration. Fluigent was the first company to introduce pressure-based flow control to handle fluids in microfluidics. Along with the MCFS-EZ or MCFS-EX, a Manifold can be added to redirect the pressure to multiple fluid reservoirs. It is available for vacuum and pressures of up to 2 bar. is well-suited technology for applications that require mobile or compact fluidic control devices, including point of care (PoC) diagnostic and testing, or for water and soil on-site analysis. 3 pressure modules consisting of two 0 2000 mbar and a -800 + 1000 mbar are connected to the main F-OEM board for pressurizing two fluidic reservoirs, allowing for pressure-based fluid handling. Configure your own system: The F-OEM consists of a main board to which one can add pressure and switch control modules depending on the configuration required. The Push-Pull integrates the all-new DFC (Direct Flow Control) algorithm. Connect the outlets of the P-SWITCH directly to quake or on-chip pneumatic valves to actuate them. Flow-rates can be monitored or controlled using Fluigent DFC self-learning flow rate control algorithm. The MFCS series products are well adapted to the manipulation of fluid volumes in the low to sub microliter per minute range. Our engineered systems tackle these limitations by bringing a cost-effective solution with a highly reduced footprint. 6). These can easily be combined tomatch all application requirementsor reconfigure the system for a new experimental design. In fact, it is possible to observe that the micropump will take more than a minute to reach zero pressure. The Fluigent LineUp series, including the new push-pull pump, enables precise and highly controlled aspiration and respiration of liquids. Most pressure controllers require a pressure source which is regulated. In this stand-alone configuration, the device allows for pressure or flow rate control and volume dispense making it ideal for benchtop use.

Our technology is an excellent fit for such applications as it is fully connected and provides excellent fluidic performance while being compact. Its patented, field-proven Fastab technology allows both fast settling times and outstanding stability. Video courtesy of Pr Satoshi Sawai ( University of Tokyo, Japan). The compact device stands near the microfluidic device, allowing the user to minimize bench space use without the need of a PC. The technology used in this pressure pumpavoids cross-contaminationbecause liquids only contact air. The set-up allows us to further advance our research in both continuous flow and droplet microfluidics.. Fluigent has delivered thousands of patented pressure-flow controllers systems to hundreds of customers worldwide. If you are seeking to replace high-precision syringe pumps or other conventional instruments, we offer modern microfluidic systems and components that enhance productivity.. 67 avenue de Fontainebleau94 270 Le Kremlin-Bictre, All-in-one pressure supply & pressure/flow control, Advantages of pressure-based microfluidics, Droplet and particle generation in microfluidics, Control in real-time, protocol automation, data record and export. & Lourdes, Basabe-Desmonts Fernando, B.-L. Microfluidics and materials for smart water monitoring: A review. The pressure controllers immediately provide the requested pressures with very high stability thanks to the feedback loop.

It can easily be connected to other microfluidic devices such as FLOW UNIT sensors to allow for flow-rate control. Combine up to 12 modules as your work flow grows. The microfluidic laboratories and industry were struggling to perform their research and develop equipment to the level and precision required in terms of fluid control.

Valve and switch platform for directing the fluid flow, including bidirectional and rotary multi-port port valves. Pressure modules (positive pressure, negative pressure, or push-pull modules), microfluidic valve modules, and flow sensors are directly connected to the main platform. The PX module is a CE and RoHS compliant single controller available in 3 pressure ranges. The Flow EZ integrates the all-new DFC (Direct Flow Control) algorithm. Fluigent has developed (patent pending) an all-in-one, free standing, compact, integrated pressure-based control with an internal pressure supply technology. Fluigent is an international company which develops, manufactures and supports the most advanced fluid control systems available for microfluidics offering greater control, automation, precision, and ease of use.. Each module is a separate and independant pressure channel. Using a pressure leakage or a valve in complement to the pump is a way to circumvent this limitation. The Flow EZ can maintain continuous, pulseless flow for days without refilling. For point-of-care applications, a touch screen can be developed based on your needs. With a compact and modular design, the Push-Pull allows you to set and benefit quickly from the pressure-based flow control advantages for your experiments. Instead of looking at the PC, users can keep their eyes on the microscope, adjusting the control dial with one hand.

Improved reliability and reproducibility of of results is possible due to the pulseless flow. The sensor can be directly connected to a PC via USB, and display measurement in real time onthe Fluigent OxyGENsoftware interface. The MFCS can be controlled by Fluigent software to automate your protocols. However, adding such leakage components influence the overall performance: the maximum pressure that can be reached has now decreased of about 15% (from 375 mbar to 310 mbar illustrated in the graph Fig. It offers excellent performance. Two pressure modules consisting of a 0 2000 mbar and -800 + 1000 mbar are connected to the main F-OEM board for pressurizing two fluidic reservoirs, allowing for pressure-based fluid handling. Conventional water monitoring is based on laboratory instruments that are generally sophisticated and expensive. The pressure automatically adjusts in the background to maintain the set flow rate. Single gateway for industrial-grade microfluidic control: The platform can be used to control a pressure source and power other third-party devices required in the microfluidic system. It is well established that pressure-based flow control offers unequaled flow stability and response times. Due to its individually stackable channels adapted for different pressures, the PX series allowed for control of the different pressure variations required. It allows optimal flow control with the reliability required for demanding industrial environments. Front. Customize your own controller to answer your control needs. The LineUp series module can be combined together to add pressure/vacuum channels, valve control and turn one channel into 8 independent outlets using the P-SWITCH. Two pressure modules consisting of a 0 2000 mbar and -800 + 1000 mbar are connected to the main F-OEM board for pressurizing two fluidic reservoirs, allowing for pressure-based fluid handling. Based on our industry leading experience, Fluigent has developed the patented QuadCore pneumatic system, the most advanced microfluidic pumping technology available. Emerging point of care applications make use of more complex fluidic operations and require compact systems. Control and regulate pressure and flow rate without a PC using the LineUp hardware interface. With the addition of a pressure leakage component, the pressure drop now takes about 5 seconds (see Fig. Migrating cells in dynamic chemical gradients generated by a microfluidic chamber (cells, gray; chemoattractant with fluorescein,green). The product line can detect values over the range of-1000 mbar(-15 psi) to7000 mbar(100 psi). For more information or a technical discussion, 67 avenue de Fontainebleau94 270 Le Kremlin-Bictre, All-in-one pressure supply & pressure/flow control, Advantages of pressure-based microfluidics, Droplet and particle generation in microfluidics. The addition of aFLOW UNITenables one tocontrol or monitor flow rateas well asmeasure a dispensed volume. 67 avenue de Fontainebleau94 270 Le Kremlin-Bictre, LineUp Series, the new generation of microfluidic controllers, All-in-one pressure supply & pressure/flow control, Advantages of pressure-based microfluidics, Droplet and particle generation in microfluidics, Dry, oil-free gas, air, any non corrosive or non explosive gas, Aqueous solvent, oil, organic solent, biological sample, Control in real-time, protocol automation, data record and export. Our LineUp product range is the next generation of microfluidic systems. This system can be integrated, automated or control in real time by using Fluigent Software Solutions. With the use of pressure instead of mechanical action, the Flow EZTMgets a responsiveness ten times faster than syringe pumps. With the Flow EZ or Push-Pull modules one can precisely regulate and control pressure & vacuum, the LINK and LINK COM modules provide communication to a computer or any external instrument using TTL ports, USB cable or Serial port communication. 4 slots for pressure or switch modules. In this stand-alone configuration, the device allows for pressure or flow rate control and volume dispense making it ideal for benchtop use. The F-OEM range of modules allows for regulation of vacuum/pressure down to -800 mbar and up to 7 bar, with the possibility to use a push-pull module (-800 / +1 000 mbar). 67 avenue de Fontainebleau94 270 Le Kremlin-Bictre, Key indicators to ensure long-term performance of your OEM flow control components, Things you should know when integrating fluidics into your system, DFC, self-learning flow rate control algorithm, Peristaltic pump vs pressure-based microfluidic flow control systems for Organ on-chip applications, Droplet generation using syringe pumps and pressure-based flow controllers, All-in-one pressure supply & pressure/flow control, Advantages of pressure-based microfluidics, Droplet and particle generation in microfluidics, Pressure : 0 to 7000 mbar (101 psi) required pressure supply 7100 mbar (103 psi), Pressure: 0 to 2000 mbar (29 psi) required pressure supply 2100 mbar (30.4 psi) min, 2400 max, Pressure: 0 to 1000 mbar (14.5 psi) required pressure supply 1100 mbar (16 psi) min, 1300 max, Pressure: 0 to 345 mbar (5 psi) required pressure supply 1100 mbar (16 psi) (600 min, 1300 max), Pressure: 0 to 69 mbar (0.9 psi) required pressure supply 150 mbar (2.18 psi), Pressure: 0 to 25 mbar (0.36 psi) required pressure supply 150 mbar (2.18 psi), Vacuum : -25 mbar (-0.36 psi) / -69 mbar (-0.9 psi) / -345 mbar (-5 psi) / -800 mbar required vacuum -800 mbar (-11.6 psi), Push-Pull : -800 mbar (-11.6 psi) to 1000 mbar (14.5 psi) required pressure 1100 mbar (16 psi) min and 1300 max and vacuum -800 mbar (-11.6 psi) (min), 0.1% of full scale CV (on measured values), Liquid flow rate sensor input, customizable to work with third party sensors (through SDK), Control up to 4 x switches or valves per module compatible with Fluigent 2 position switches and rotary valves (M-switch, L-switch, 2-switch), Pressurized or bottled clean dry and non-corrosive or explosive gas (Ambient air, N2, Ar, CO2) (02 could be a thing, need to check), OD 4mm female push in fitting (on standard version, can be fittingless, then it is an M5 thread), >1W groundable for F-OEM platform (can be increased depending on peripherals, eg pump, fans etc) 6W maximum per FEZ module, 48W maximum per SWEZ module (rotary valves ~ 12W), External power, 2A or 7A available from standard, but custom can be accepted using MBPT terminal block connection, USB (standard board), RS232 (alternative board) + other protocols on demand, RJ45 female (or 2wire terminal block for SWEZ lite), 0-24VDC, digital controlled output 5 or 24 volts selectable, 2 x USB2.0 ports (available only on the USB connection protocol version, 0.1 Kg (F-OEM platform), 0.4 Kg (per pressure module with manifold), 0.3 kg (per switch module), Main electronic board. Control and handle the fluid on the chip without additional tubing. Fluigents unique broad range of solutions for use in microfluidic and nanofluidics applications ensure full control of flow rates with a greater control, automation, precision, ease of use and also minimize contamination. Instead of looking at the PC, users can keep their eyes on the microscope, adjusting the control dial with one hand. The MFCS system can provide negative or positive pressures as needed by using up to four or eight independently controllable channels. Bioeng. Flow sensors are connected for flow rate monitoring and control. Fig 1: (left) A pressure supply and pressure controller vs our new technology (right) Fluigent engineered technology.

Janire, S., Raquel, C.-C., R_oisn, M. O. By using the FASTAB microfluidic patented technology, the MFCS generates a constant pressure-driven flow rate that allows for reliable and repeatable experiments. 8, 114 (2021). Using this engineered solution, pressure drop takes less than a second, and the maximum pressure reachable has not deteriorated (see graph). Combine as many modules as you want to fit your application needs. The Push-Pull can maintain continuous, pulseless flow for days without refilling. The Flow EZ range of modules allow for regulatation of pressure / vacuum down to -800 mbar and up to 7 bar. Pressurize up to 32 reservoirs simultaneously or independently. TheLineUpPush-Pullis a standalone controller with the ability to deliverfinely regulated pressureor avacuumthrough a single outlet over the range of-800 to +1000 mbar. There are many advantages to direct control: Configuration 1: 2 pressure modules. Plug directly the sensor to the PC and benefit from a compact solution for pressure detection. https://cordis.europa.eu/article/id/421573-microfluidics-is-the-future-of-agriculture-with-on-site-soil-analysis, Development of complete device based on your needs, 67 avenue de Fontainebleau94 270 Le Kremlin-Bictre, (Patent pending) compact all-in-one pressure supply & pressure/flow control, Things you should know when integrating fluidics into your system, All-in-one pressure supply & pressure/flow control, Advantages of pressure-based microfluidics, Droplet and particle generation in microfluidics, All in one micropump for pressure source and control, Need to be connected to an external pressure source and power supply, Pressure: Up to 600 mbar (for a single pump), No overshoot/undershoot, allowing for an immediate highly accurate and stable flow, Useful over a wide pressure or vacuum range (up to 600 mbar, -400 mbar vacuum, standalone pressure/vacuum regulation capability). When combined with a FLOW UNIT, one can control flow rate directly or deliver dispensed volumes as needed. It has been designed to maximize versatility with its dual interface USB and RS232 ports and is delivered with a full software package (SDK) to ease integration into Windows or Linux-based software platforms. Sachdeva, S., Davis, R. W. & Saha, A. K. Microfluidic Point-of-Care Testing: Commercial Landscape and Future Directions. Explore Fluigent industrial. Support reservoir sizes from 2 mL to one liter laboratory bottles. 67 avenue de Fontainebleau94 270 Le Kremlin-Bictre, Success story of SEED Biosciences : Single-cell injection and impedance analysis, University of Cambridge: Giant unilamellar vesicle production and testing, The Micro/Nano Bioelectronics and Biosensors (MBIOS) from Tianjin University, Microbiome culture in droplet using dsurf surfactant, Droplet and particle manipulation using electrophoretic flow control, Cartilage on chip using Fluigent MFCS pressure controller, Fluid recirculation for cell perfusion with reduced shear stress, Droplet generation using syringe pumps and pressure-based flow controllers, Extended capabilities of pressure driven flow for microfluidics applications, All-in-one pressure supply & pressure/flow control, Advantages of pressure-based microfluidics, Droplet and particle generation in microfluidics, Highly monodispersed droplet size No oscillation, No transitory regime Reagent saving Stop-flows, Wide range of volume can be controlled No compromise between volume and stability, Any mix or pressure ranges are available Highly customizable, Female luer lock (-800 to 2000 mbar) 4mm OD tube (7 bar), Dry, oil-free gas, air, any non corrosive or non explosive gas, Aqueous solvent, oil, organic solent, biological sample, Control in real-time, protocol automation, data record and export.



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