PharmaTutor Mag. Flowers by botanical names-, iloveindia.com . As per an ancient Indian medicinal scriptureCharaka Samhitathis plant is superior to other nootropic drugs (Medhya rasayana) of Ayurveda, however, a detailed ethnomedicinal update yet needs to be presented (Dev, 2006). Int. Such evident analgesic activity is cohesively attributed by flavonoids, volatile oils, alkaloids, polyphenols and organic acids by means of prevention of the formation of cyclooxygenase enzyme and prostaglandins, i.e., mediators of pain sensitization. doi: 10.1007/978-981-13-0289-3_13, Sethiya, N. K., Nahata, A., Mishra, S. H., Dixit, V. K. (2009). If taken in the proper dosage, one can steer clear of the side effects and enjoy the countless health benefits. A comparative pharmacognostic study on Shankhpuspi-, Bihaqi SW, Sharma M, Singh AP, Tiwari M. Neuroprotective role of, Verma S, Sinha R, Kumar P, Amin F, Jain J, Tanwar S. Study of, Dhingra D, Valecha R. Screening for antidepressant-like activity of, Nahata A, Patil UK, Dixit VK. Old and new natural products as the source of modern antithrombotic drugs. Learning behavior and memory enhancement activity, 100 mg/kg/passive avoidance paradigms and active avoidance test, 200 mg/kg/passive avoidance paradigms and active avoidance test. 30, 13171323. Appl. The flowers are blue in color (5 mm) and the leaves, which are elliptic in shape (2 mm), are located at alternate positions with branches or flowers. Trivedi, P. C. (2009). Shankapushpi. Int. In another experiments, it has been shown that the oral administration of the aqueous extract of the CP roots (150 mg/Kg) to scopolamine induced rats causes a marked reduction in the mRNA levels of tau protein (Bihaqi etal., 2012). Int. It also helps in enhancing concentration, learning capabilities, mental fatigue, insomnia, stress, anxiety, depression, etc. It mostly occurs due to excessive work using a computer, watching television for hours, learning or memorizing activities, etc. Anti-nociceptive effect of 7-methoxy coumarin from Eupatorium Triplinerve vahl (Asteraceae). B., et al. C. prostratus belongs to Convolvulaceae family and is ubiquitous in the north-western regions of India (Nisar etal., 2012). doi: 10.2174/187152809788681029, Ravichandra, V. D., Ramesh, C., Sridhar, K. A. J. Exp. It is used in Ayurvedic formulation for chronic cough, sleeplessness, epilepsy, hallucinations, anxiety etc. Boil 1 teaspoon of shankhpushpi powder with a cup of water. These include Evolvulus alsinoides Linn, Clitoria ternatea Linn and Canscora decussata Schult. There is a pertinent reference in Ayurvedic literature about the use of the drug as brain tonic in hypotensive syndromes. Biobehav. Herbal remedies for neurodegenerative disorder (alzheimer's disease): a review. (2012). The author cited different papers in his manuscript to support the therapeutic potential of C. pluricaulis in traditional medicine. Ch., Ramanamam, V., Ram, S. S., Sudershan, M., et al. J. 1, 4451. In Indian medicinal system Ayurveda it is named as Shankhpushpi. Bethesda, MD 20894, Web Policies Herbal option for diabetes: an overview. 28, 6268. The human brain book: An illustrated guide to its structure, function, and disorders (London: Penguin publishers). The neuro-mechanistic aspects of this herb has been elucidated in Figure1A. A brain tonic imbued with potent Medhya traits, Shankhpushpi is highly significant in dealing with hysteria as it effectively works as a stimulant and boosts the function of the brain. The herb is extremely beneficial and is used from root to tips for its wide range of therapeutic benefits. Used on a daily basis, it is extremely beneficial to boost memory. The powerful antioxidants and flavonoids present in it improve the memory capacity, focus, concentration, calmness, alertness of an individual. The ethanolic and methanolic extracts of the whole plant reduced spontaneous motor activity, potentiated pentobarbitone hypnosis and morphine analgesia, reduced fighting response, abolished the conditioned avoidance response, antagonized convulsive seizures and tremorine induced tremors in mice. Res. Fungitoxic effect of scopolin and related coumarins on Sclerotinia sclerotiorum - A way to overcome sunflower head rot. It is also attached to mental health as the individual suffers from low weight issues, fear of gaining weight, lower self-esteem and an intense desire to reduce weight. doi:10.3109/13880209.2011.584539, Malik, S., Ahmad, S., Sadiq, A., Alam, K., Wariss, H. M., Ahmad, I., et al. Moreover, the CP powder and juice, such as, Jain Shankhpushpi Powder and Axiom Jeevan Ras Shankhpushpi Juice, are also being used as skin mask for rejuvenating the skin and managing skin problems such as acne, blemishes and sun spots (Hindu, 2012). An update on Shankhpushpi, a cognition-boosting Ayurvedic medicine. 9, 99102. (2018). 20 Articles, This article is part of the Research Topic, Phytomedicinal Formulations Containing C. prostratus, Neuro-Pharmacological Profile of C. prostratus, https://www.ijser.org/paper/Estimation-of-elemental-concentrations-of-Indian-medicinal-plants-using-Energy-dispersive-X-ray-fluorescence.html, https://www.ijpp.com/IJPP%20archives/1965_9_2/99-102.pdf, https://www.semanticscholar.org/paper/Ethnobotany%2C-Phytochemistry-and-Pharmacology-of-Bhalerao-Verma/62602df9affb6d3a5a27699015e1506aa34ef1bf, http://www.phytojournal.com/vol1Issue1/Issue_may_2012/4.pdf, https://www.semanticscholar.org/paper/SCREENING-FOR-ANTIDEPRESSANT-LIKE-ACTIVITY-OF-IN-Dhingra-Valecha/51168240f3c88647a52ce21a54878606c61a7c66, https://irjponline.com/admin/php/uploads/794_pdf.pdf, https://hero.epa.gov/hero/index.cfm/reference/details/reference_id/1109757, http://www.thepharmajournal.com/archives/?year=2016&vol=5&issue=1&ArticleId=695, https://pdfs.semanticscholar.org/1dc0/39b0046a0caa7e211b7a64f0ec91596d4fef.pdf, https://www.pharmatutor.org/articles/development-high-performance-thin-layer-chromatography-method-for-determination-scopolin-convolvulus-pluricaulis-chois?page=1%2C1, https://www.researchgate.net/publication/266140204_Hypolipidemic_effect_of_Convolvulus_microphyllus_in_cholesterol_fed_gerbils_Meriones_hurrinae_Jerdon, https://www.semanticscholar.org/paper/Review-on-ethnomedicinal-uses-and-of-memory-herb-Sethiya-Mishra/427692942318bd7bf5c9cd65e2cf8627aaa9c61f, http://globalresearchonline.net/journalcontents/v23-2/36.pdf, https://www.semanticscholar.org/paper/REVIEW-OF-SANKHAHAULI-(CONVOLVULUS-PLURICAULIS-FROM-Nisar-Khan/0994b296aed35c7b9ccaa97be1505fddf55218e8, https://www.ijam.co.in/index.php/ijam/article/view/163, https://ijpbs.net/abstract.php?article=NTk2, http://nopr.niscair.res.in/handle/123456789/27919, http://www.phytojournal.com/archives/2013/vol2issue4/PartB/23.1.pdf, https://pdfs.semanticscholar.org/696f/2e4d7280727d2baba08bc7c6e3a7cd03ef3a.pdf, Creative Commons Attribution License (CC BY). Chaudhary, R. D. (1996). Int. Hindu, V. (2012). Expansion of research materials would provide more opportunities for the discovery of new bioactive principles from C. pluricaulis. Traditional and folk herbal medicine: Recent researches (Vol. Medicinal plants: Utilization and conservation. Indian J. Trad. It ultimately acts as a sedative moiety which initiates a persistent fall in blood pressure and cardiac contraction, thereby managing neurological pathologies, such as anxiety, insanity and epilepsy (Chaudhary, 1996). India: Tabish; 2005. Also Read: Five Common Types Of Headaches: Causes, Symptoms And Treatment. Free Radic. The chloroform, ethanol and aqueous extracts of CP have been evaluated for anti-convulsant activity against strychnine induced as well as pentylene tetrazol (PTZ) induced convulsive seizures in different animal models. The holistic science of ayurveda popularizes shankhpushpi in various rasayanas or formulations and scriptures by the Sanskrit names Shyamakranta, Visnukranta, Vaishnava, Sankhaholi, Vishnugandhi, Vishnukranti, Shankavall, Vishnukrantha, Krishnaenkranti, Nilashankhapushpi, Ksheerpushpi, Laghuvishnukranta, Erravishnukaraantha. Acute Dis. 11, 6268. Ethnobotany of Rajasthan (Jodhpur, India: Scientific Publishers). The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Epidemiology of neurological disorders in India: Review of background, prevalence and incidence of epilepsy, stroke, Parkinson's disease and tremors. This paper covers the literature, primarily pharmacological, from 1985 to the end of 2012. 2, 94101. [Online]. CP also acts as GABA-A agonists and binds to lateral prefrontal cortex (O) and anterior cingulate cortex (N). 3, 8287. Kaempferol suppresses collagen-induced platelet activation by inhibiting NADPH oxidase and protecting SHP-2 from oxidative inactivation. Hydroxy-cinnamic acid is a phenyl-propanoid compound found in CP. Ethnobotany, phytochemistry and pharmacology of Convolvulus pluricaulis, Choisy. J. Institut. More specifically, a compound, namely, 29-oxodotriacontanol, isolated from the CP herb has also been assessed to possess antimicrobial and anti-fungal activity (Amin etal., 2014). NGF-dependent neurons and neurobiology of emotions and feelings: Lessons from congenital insensitivity to pain with anhidrosis. Pharm. 22 (1), 1925. (2001). (2018). Massaging the forehead and scalp with the oil relieves from stress and headache. EPM test has mainly been used to investigate the interactions between aversive memory and anxiety responses of the mice.
Biol. Interestingly, the ethanolic and aqueous extracts of the CP aerial parts showed statistical significant potentiation of sleeping time in rats induced with thiopental sodium (Siddiqui etal., 2014). Five hundred mg/Kg concentration of the CP extracts have shown statistically significant (p < 0.001) protection against strychnine and PTZ induced clonic convulsions (Ratha and Mishra, 2012; Siddiqui etal., 2014). Shankhpushpi characterizes Tikta Rasa (bitter taste). CP plant is known to contain kaempferol, -sitosterol, N-hexacosanol, taraxerol, taraxerone, delphinidine and hydroxy-cinnamic acid as the major phyto-constituents, as depicted in Table 2 (Billore etal., 2005; Amin etal., 2014). (2018). Pharmacological and biochemical evidence for the antidepressant effect of the herbal preparation Trans-01. Similarly, the iron oxide nanoparticles of the CP herb exhibited maximum tolerable dose up to 2,000 mg/Kg in Swiss albino mice with no clinical signs of toxicity. Behav. Available at https://www.semanticscholar.org/paper/REVIEW-OF-SANKHAHAULI-(CONVOLVULUS-PLURICAULIS-FROM-Nisar-Khan/0994b296aed35c7b9ccaa97be1505fddf55218e8. Integr.
39 (5), 231234. Review of possible mechanisms of analgesic effect of herbs and herbal active ingredient. Well-known as morning-glory, speed wheel or Aloe weed in English, this medicinal herb has specific arrowhead-shaped leaves and bulb-shaped blue or white flowers. Reported mechanisms of CNS action of CP phyto-constituents has been depicted in these schematics, with putative site of action has been marked with fluorescent green blobs.
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