56. Smith EB. Fisher G, No microscopy for any participant, Data combined for three sites; tinea pedis, tinea cruris, tinea corporis, Culture is used to identify pathogens at baseline but not to assess outcome, Results for mycological cure do not separate out those for tinea pedis from tinea cruris, Cannot separate tinea pedis results from those of tinea corporis and inguilalis. Patient aims to help the world proactively manage its healthcare, supplying evidence-based information on a wide range of medical and health topics to patients and health professionals. Anderson C, A randomised trial of acidified nitrite cream in the treatment of tinea pedis, Treatment of tinea pedis with sulconazole nitrate 1% cream or miconazole nitrate 2% cream, Amorolfine in the treatment of onychomycosis and dermatomycosis: an overview. However only seven trials did not report blinding of subjects (Smith 1988a; Smith 1988b; Smith 1988c; Friederich 1992; Sanchez 1994; Roberts 1985; Friederich 1992). Twentyfive trials compared two active treatment regimens (Bojanovsky 1985; Carter 1972; Del Palacio 1989; Evans 1993a; Evans 1993b; Friederich 1992; Haas 1985; Holti 1970; Kagawa 1985; Kligman 1985bKuhlwein 1990; Leenutaphong 1999; Plotkin 1990; Pereda 2003; Qadripur 1979; Roberts 1985; Sanchez 1994Schopf 1999Smith 1988b; Smith 1988c; Smith 1992; Sushka 2001; Vermeer 1996; Weller 1998; Woscoff 1986). Oliver V, Do not give it to other people even if their condition appears to be the same as yours. Jones T, Kornberg R, Comparison 1 Allylamines vs Placebo, Outcome 1 Short term (2 weeks) treatment failure. Li Q, ( YEAST or SPORE or SPORES ) ti,ab,sh. If this happens, stop the treatment for a few days to allow your skin to recover and then re-start treatment. A comparison with miconazole in the treatemnt of tinea pedis and tinea cruris corporis. Each trial is plotted using a circle with size proportional to the standard error of the treatment effect so that trials providing more precise estimates are shown using larger circles. (fung* or hypha* or yeast* or spore*)
Berman B, Bifonazole versus miconazole Galbiati G, In a trial comparing 4 weeks of 1% clotrimazole with 1 week of 1% clotrimazole Bergstresser 1993 found a statistically significant relative reduction in treatment failure of 53% favouring the longer treatment time (RR at 12 weeks 0.47, 95% CI 0.28 to 0.78; Analysis 5.4). Ogawa H, Cuetara S, Comparison 6 Allylamines 12 weeks vs Azoles 12 weeks, Outcome 1 Short term (2 weeks) treatment failure. A statistically significant effect of butenafine(1%) was observed when it was used for 1 week and for 4 weeks.
Bifonazole versus croconazole We identified 11 trials evaluating the efficacy of topical treatments for nails and included 6 in the review (Buck 1994; Gupta 2000a; Gupta 2000b; Mensing 1992; Montana 1994; Syed 1999). (miconazole or daktarin or (benzoyl next peroxide) or amorolfine or loceryl or clotrimazole or canestin or masnoderm) Bergstrasser PR, 1. Outcomes at 36 weeks, 2.1 Amorolfine 5% + methylene versus Amorolfine 5% + ethanol outcomes at 3 days, A. Upgrade to Patient Pro Medical Professional? Gip L, Cole GW, Cowen P, Across all 9 trials providing shortterm outcome of 1% allylamines for a period of 1 to 2 weeks compared with placebo, there was a pooled relative reduction in treatment failure at 2 weeks of 31% (RR 0.69, 95% CI 0.56 to 0.87; Analysis 1.1), with substantial variation in individual study results (I2 = 79%). Most trials achieved at least 80% followup at 6 weeks, apart from Bergstresser 1993 and Smith 1988c. They are thought to occur when individuals regularly use communal changing rooms and swimming pools. 7. Cohen A, Only > 80% followup included. Pye RJ. Rex IH, Nolting S, 2. Tea tree oil versus tolnaftate Griffin TB, Palacio A, et al. Parish LC, No. 10. (#22 or #23 or #24) Sefton J.
Protocol first published: Issue 1, 1999 PROSPECTIVE STUDIES.sh. 61 AND ( 11 OR 22 OR 30 ). Data collected at 12 weeks from one trial (n = 75, Bergstresser 1993) comparing 1% allylamines (terbinafine) with 1% azoles (clotrimazole) used for 1 to 2 weeks produced a statistically significant relative reduction in treatment failure of 72% (RR 0.28, 95% CI 0.14 to 0.58; Analysis 6.4), favouring allylamines. ( NAIL or NAILS ) ti,ab,sh. 8600 Rockville Pike (b) nail maintenance of cure 36 weeks after initiation of intervention. If you are using a topical liquid or a paint, these may be flammable, so do not apply either of them near flames or an open fire. It is usual to apply most preparations once each day. Of the 144 identified papers, 67 trials met the inclusion criteria. Infection is normally restricted to the outermost layer of the skin (epidermis). Comparison 11 Comparisons between other topical antifungal treatments, Outcome 3 Long term (12 weeks onwards) treatment failure. Saurajen A, Combining data from 3 of the trials which had at least 80% followup (n = 685, Evans 1993b; Leenutaphong 1999; Schopf 1999) also did not show a statistically different difference in the treatment failure rates (RR 0.50, 95% CI 0.10 to 2.54; Analysis 7.2). Tolciclate Ali SM, Evans 1994 compared terbinafine applied for 5 to 7 days with terbinafine applied for 1 to 2 days (n = 65), no statistical difference was detected in the treatment failure rates (RR of treatment failure 0.89, 95% CI 0.31 to 2.50; Analysis 4.2). McGibbon DH, Salicylic Acid Powder | Ringworm Treatment | salicylic acid powder for fungal infection |daad dad ki dawa Dosto es vedio me dad ko hamesha ke liye thik karane ki dawa ke bare me jankari di gayi hai. Wood P, National Library of Medicine The method of allocation was reported in only 17 trials (Ablon 1996; Akers 1989; Buck 1994; Chretien 1980; Evans 1993a; Evans 1993b; Evans 1994; Fuerst 1980; Gentles 1974; Holti 1970; Kligman 1985a; Kligman 1985b; Korting 1997; Mandy 1974; Plotkin 1990; Savin 1997; Smith 1977). 34. Howard W, Evans EGV, et al. For help with the update of this review and the previous version we thank: Sally BellSyer, Kath Cross, Zelda Di Blasi, Alison Eastwood, Annelise Emmans, Jill Ferrari, Nick Freemantle, Simon Gilbody, Mark Goodfield, Rod Hay, Mark Petticrew, Daphne Russell, Ian Russell, David Torgerson, Trevor Sheldon, Fujian Song, Wendy Tyrrell, Hywel Williams and the Cochrane Skin Group, and Philip Young. Tortoriello J. Vaananen A, Maloney JM, Rosenberg M, Houwelingen JC. 39. 51. Lasser AE, DOI: 10.1002/14651858.CD012093. Manufacturer's PIL, Salatac Gel; Dermal Laboratories Ltd, The electronic Medicines Compendium. Lapiere CM. {"type":"entrez-nucleotide","attrs":{"text":"CD012093","term_id":"30328831","term_text":"CD012093"}}, 2 Medium term (6 weeks) treatment failure, 3 Medium term (6 weeks) treatment failure. Further research into the effectiveness of antifungal agents for nail infections is required. 
It may take two weeks or more before you notice any improvement and it can take up to three months of daily applications for warts to go completely. Data collected at 6 weeks in 5 trials (n = 962, Bergstresser 1993; Evans 1993a; Leenutaphong 1999; Schopf 1999; Vermeer 1996) which compared a 1% allylamine (terbinafine) used for 1 week with an 1% azole used for 4 weeks (clotrimazole, miconazole) did not show a statistically significant difference in treatment failure (RR 0.75, 95% CI 0.33 to 1.72; Analysis 7.1). Rohwedder R, Bell C, The skin between the toes is a frequent site of fungal infection (athlete's foot or tinea pedis and this can cause pain and itchiness. At 4 weeks there was 100% followup, and an RR of treatment failure of 1.71 (95% CI 0.54 to 5.42; Analysis 10.3). Brautigam M, Our clinical information is certified to meet NHS England's Information Standard.Read more. We searched the bibliographies of all the papers identified by these strategies. (ix) were adverse events reported. The concentration of these drugs was generally 1%, but 2% for miconazole, they were used for 4 to 6 weeks. Twentynine trials compared a single active treatment with placebo (Akers 1989; Aly 2003; Bagatell 1986; Bagatell 1991a; Bagatell 1991b; Berman 1992; Chretien 1980; Coffey 1986; Dobson 1989; Evans 1991; Gentles 1974; Gomez 1986; Ison 1990; Izuno 1986; Klaschka 1984; Kligman 1985a; Korting 2001; Mandy 1974; Savin 1990; Savin 1994; Savin 1997; Schachner 1990; Smith 1977; Smith 1986; Smith 1988a; Smith 1990a; Spiekermann 1976a; Spiekermann 1976b; Tschen 1997). a. Terbinafine cream 1% 7 days once daily. A new treatment for cutaneous candidiasis sulconazole nitrate cream 1%, Usefulness of lanoconazole (Astat) cream in the treatment of hyperkeratotic type tinea pedis. Please see Characteristics of excluded studies. ONYCHOMYCOSIS The antibacterial efficacy of econazole nitrate in interdigital toe web infections, Haloprogen therapy for dermatophyte infections. Ellis C, EPIDERMOPHYTON Hadi SM, The written report of the study is too confusing to be able to extract the appropriate data, Combined data for hands and feet infections, No mycological assessment was carried out, Compares systemic treatment with topical treatment, Study looks at bacterial infection as well as fungal infection and does not separate the results, Cannot separate mycological results for tinea pedis of the skin from infection of the nail, One hundred and four (104/217) only had culture confirmed at baseline. For skin infections we included only trials that used microscopy and culture to establish the presence of dermatophytes. Bagatell FK, We have written a published note to say that we decided to split the topic into topical and devicebased treatments for fungal infections of the toenails and topical treatments for athlete's foot, so a protocol and then a new review will be written. We searched the Current Controlled Trials Register (on www.controlledtrials.com) and www.clinicaltrials.gov in January 2005 for ongoing trials.
Ali SM, All the randomised evaluations included in this systematic review of tea tree oil suggest that it is ineffective in the management of fungal skin infections. Stettendorf S. Treatment of onychomycosis: a randomised double blind comparison study with topical bifonazoleurea ointment alone and in combination with short duration oral griseofulvin, Miconazole therapy for endemic fungal disease. Landow RK, Sulconazole nitrate 1% cream in the treatment of chronic moccasin type tinea pedis caused by trichophyton rubrum, Journal the of American Academy of Dermatology. Only >=80% followup included.. A systematic review of the various therapies used in the topical treatment of fungal infections affecting the skin and nails of the foot will help to inform the treatment approach of all these professionals. Side effects as measured by the frequency of reported adverse events. The Korde KM, Schachner LA, 5. It is a keratolytic, which means that it works by softening the outer layer of your skin allowing it to loosen and shed. Tietz HJ, A trial of 1% clotrimazole solution performed better than 100% tea tree oil, though not significantly (Buck 1994). Cuce LC, Data collected in the trial of terbinafine used for 57 days versus terbinafine used for 13 days (n = 65, Evans 1994) found slightly less treatment failures with 57 days treatment, but the difference was not statistically significant (RR of treatment failure at 12 weeks 0.53, 95% CI 0.15 to 1.88; Analysis 4.4). All types of intervention were considered. Topical terbinafine and clotrimazole in interdigital tinea pedis: a multicentre comparison of cure and relapse rates with 1 and 4 week treatment regimens, Journal of the American Academy of Dermatology. Consult a doctor or other health care professional for diagnosis and treatment of medical conditions.
Only >=80% followup included. Bifonazole versus amorolfine FC and SH jointly wrote the text of the review and are both guarantors of the work. Shupack J, To make sure this is the right treatment for you, before you start using salicylic acid it is important that your doctor or pharmacist knows: Salicylic acid can cause skin irritation, dryness, or soreness. Resl V. Efficacy and tolerability of terbinafine 1% topical solution used for 1 week compared with 4 weeks clotrimazole 1% topical solution in the treatment of interdigital tinea pedis: a randomized, doubleblind, multicentre, 8week clinical trial, Treatment of interdigital tinea pedis and tinea (pityriasis) versicolour with bifonazole 1% solution applied once daily. et al. Rosenberg MJ, Comparison 3 Other topical antifungal treatments vs Placebo, Outcome 2 Medium term (6 weeks) treatment failure. SanchezAlor G. Topical treatment of dermatophytosis and cutaneous candidosis with flutrimazole 1% cream: doubleblind, randomised comparative trial with ketoconazole cream. Direct comparisons of allylamines versus azoles show allylamines to be generally more efficacious than azoles. Comparison between undeclynic acid and tolnaftate in the treatment of tinea pedis, Efficacy of miconazole in the topical treatment of tinea pedis in sportsmen. Sharpe LM, We listed nonrandomised controlled studies but did not discuss them further. Tea tree oil versus tea tree oil Naftifine twice daily A meta analysis of data collected in nine trials (n = 1003, Bergstresser 1993; Bojanovsky 1985; Evans 1993a; Haas 1985; Kagawa 1985; Plotkin 1990; Sanchez 1994; Smith 1990b; Smith 1992) found a statistically significant difference between 1% allylamines (naftifine, terbinafine) and 1% to 2% azoles (bifonazole, clotrimazole) used for 4 to 6 weeks, with a relative reduction in treatment failure of 37% favouring allylamines (RR 0.63, 95% CI 0.42 to 0.94; Analysis 8.1). NHS Economic Evaluation Database Korting HC, Doubleblind comparison of econazole spray powder and placebo as therapy and prophylaxis of athlete's foot. ( ECONAZOLE NITRATE or ECOSTATIN or PEVARYL or TIOCONAZOLE or TROSYL ) ti,ab,sh.
Weidinger G, 2. 2% undecylenic acid and 20% zinc acid powder, a. Oxiconazole nitrate 1% and fluticazole 0.05% combination cream, Data extracted only for patients who were microscopy and culture positive at baseline only, Data extracted for positive culture at baseline only. Two authors checked titles and abstracts identified from the searches. Ciclopiroxolamine Overall, a metaanalysis of data from 13 trials (n = 1235, Akers 1989; Bagatell 1986; Coffey 1986; Elewski 1996; Ellis 1989; Izuno 1986; Gentles 1974; Mandy 1974; Smith 1977; Smith 1986; Smith 1988a; Spiekermann 1976a; Spiekermann 1976b) comparing azoles with placebo estimated the pooled relative reduction in treatment failure as 60% (RR 0.40, 95% CI 0.35 to 0.46; Analysis 2.2).
6. Take the container with you, even if it is empty. Study only looks at culture results and not mycology. Ravichandran G, Smith EB, HHS Vulnerability Disclosure, Help The saftey and efficacy of Naftifine cream 1% in the treatment of tinea pedis. Kinnunen T, Some trials were funded by industry however a sensitivity analysis of data from trials comparing allylamines versus azoles found no statistical differences between industry funded and nonindustry funded studies. The results were inconsistent between studies, giving an overall relative reduction in treatment failure of 42% which was not statistically significant (RR 0.58, 95% CI 0.31 to 1.08; Analysis 1.1). Vigue C, Ellis D, Pooling across all durations, a 77% relative reduction in treatment failure was observed (RR 0.23, 95% CI 0.15 to 0.38, pooled result not shown in the Forest plots (MetaView), with moderate variation in individual study results (I2 = 50%). Rapini RP, One trial (Kuhlwein 1990) found 100% rate of treatment success in both arms of a small trial (n = 36) comparing 1% bifonazole for 3 weeks with 1% croconazole for 3 weeks. Dromgoole SH, One trial (n = 313, Korting 1997) evaluated 1% econazole gel versus 1% econazole cream but did not show a statistically significant difference in rates of treatment failure (RR of treatment failure = 0.78, 5% CI 0.53 to 1.16; Analysis 5.2). Smith E, Sulconazole versus clotrimazole in the treatment of dermatophytosis, Treatment of dermatomycoses with naftifine: therapeutic efficacy on application once daily and twice daily, A doubleblind study comparing Daktacort, miconazole and hydrocortisone in inflammatory skin infections. Atton AV, ( FOOT or FEET ) ti,ab,sh. sharing sensitive information, make sure youre on a federal Way B, Hickman JG, Twelve studies evaluating topical treatments for skin infections which were included in the previous version of this review were excluded in this update (Daily 1985; Duncan 1975; Thomas 1976; Ortiz 1978; Tschen 1979; Smith 1977b; Fredriksson 1982; Privat 1982; Thomas 1986; Greer 1986; Tanenbaum 1982; Tsuboi 1996). Ciclopirox gel in the treatment of patients with interdigital tinea pedis, Elimination of dermatophytes causing tinea pedis interdigitalis with once daily application of bifonazole 1% solution. In: Urabe H, editor, Doubleblind parallel comparison of sulconazole nitrate 1% cream and powder with econazole 1% cream and powder in the treatment of cutaneous dermophytoses, Topical treatment of onychomycosis with Almorolfine 5% nail laquer: comparative efficacy and tolerability of once weekly use.
Karvonen J. Efficacy and tolerability of terbinafine 1% emulsion gel in patients with tinea pedis, European Academy of Dermatology and Venereology, A double blind controlled trial of Whitfield's ointment and Variotin in ringworm infections with a two year 'followup, Once daily application of econazole nitrate in the treatment of tinea pedis, A double blind study of bifonazole 1% cream applied once daily in the treatment of tinea (pityriasis) veriscolor and tinea pedis interdigitalis, Comparative clinical trial of Naftifine and Clotrimazole in Tinea pedum, Tinea cruris and Tinea corporis, Antimycotic naftifine. A diagnosis of athlete's foot based on clinical signs and symptoms alone can be inaccurate because there are nonfungal skin conditions which have a similar appearance, e.g. Pazos C, Comparison 8 Allylamines 46 weeks vs Azoles 46 weeks, Outcome 2 Medium term (6 weeks) treatment failure. Cuetara S, (dermatophyt* or dermatomycos*) FOOT DERMATOSES In the update of the review we have only included studies which subject all skin and nail samples to KOH (potassium hydroxide) and culture). 47. Ellis CN, Aly R, Miconazole nitrate versus sulconazole nitrate Ciclopiroxolamine Bergstraesser M, LASINT06 Study Group. Comparison 8 Allylamines 46 weeks vs Azoles 46 weeks, Outcome 1 Medium term (6 weeks) treatment failure. Drake LA, Becker LE, Comparison 4 Comparisons between different allylamines or allylamine regimes, Outcome 4 Long term (12 weeks onwards) treatment failure. 5% amorolfine in a methylene chloride vehicle. Hebet AA, Dated March 2015. Thorne EG. Butenafine Pollock AC, #Healthtec #ringworm #dad #khujli#salicylicacid thanks-------------------health tec In 1 small trial 2 amorolfine 5% nail lacquer formulations with different vehicles used twice weekly for 4 weeks both achieved a relative risk of 1.00; 95% CI 0.85 to 1.18; Analysis 12.2, at both 3 and 14 days after the end of treatment. ( BENZOIC ACID or SULCANAZOLE NITRATE or EXELDERM or MYCIL or TINEAFAX ) ti,ab,sh. Better results were observed with the use of amorolfine lacquer; 6% treatment failure rates were found after 1 month of treatment but these data were collected on a very small sample of people and these high rates of success might be unreliable. Bowen RG. Effectiveness and tolerability of a standard phytodrugderived from solanum chrysitrichum on tinea pedis: a randomised clinical trial. : {"type":"entrez-nucleotide","attrs":{"text":"CD012093","term_id":"30328831","term_text":"CD012093"}}CD012093. Marley J,
(#2 or #3 or #5 or #6 or #7 or #8 or #9 or #10 or #11 or #12 or #13) We searched the Cochrane Skin Group Specialised Register (January 2005), the Cochrane Central Register of Controlled Trials (The Cochrane Library Issue 1, 2005), MEDLINE and EMBASE (from inception to January 2005). Qin LM, To assess the effects of topical treatments in successfully treating (rate of treatment failure) fungal infections of the skin of the feet and toenails and in preventing recurrence. ANIMAL.sh. In the trial by Smith 1990b (n = 117) no statistically significant difference was observed at 2 weeks between naftifine used once daily or twice daily (RR of treatment failure at 2 weeks 0.92, 95% CI 0.72 to 1.17; Analysis 4.1). 15. A trial comparing 50% tea tree oil versus 25% tea tree oil (n = 69, Satchell 2002) did not show a statistically significant difference in treatment failures (RR 0.79, 95% 0.45 to 1.41; Analysis 11.2). James IGV, et al.
Warin AP. We looked at the included RCTs for reports of adverse effects of the interventions. i have been born with bended toes and i never payed attention to it but my toes are crooked , they give me corns and it hurts. Comparison 6 Allylamines 12 weeks vs Azoles 12 weeks, Outcome 2 Medium term (6 weeks) treatment failure. Palacio A, There was considerable variation in the results of the individual trials (I2 = 60%). ti,ab. Dodman B, changes in the nail shape or colour compared to 5 participants in the vehicle group; 3 participants in the ciclopiroxolamine group showed an application site disorder compared to 3 participants in the vehicle group (Gupta 2000a; Gupta 2000b). Czernielewski J.
Creams, lotions and gels (topical treatments) for fungal infections of the skin and nails of the foot. Dermatophytes have the ability to invade keratinised tissue (skin, hair and nails). PLACEBOS.sh. Comparison 1 Allylamines vs Placebo, Outcome 2 Medium term (6 weeks) treatment failure. LopezGomez S, Pariser DM. Leenutaphong V, Liu WD, The diagonal line indicates no treatment effect (RR = 1). Tee tree oil Measurement of recurrence of the condition in: (a) skin maintenance of cure 12 weeks after initiation of intervention. FC ran the searches, extracted data and applied the QA tool to the additional studies. Combined data for dermatophytes and candida, Studies effect of treatment on candidiasis, not dermatophytes, Fungi demnstrated by direct microscopic exam OR culture, Unit of analysis sites not patients unclear as to the numbers of units in study. Clinical efficacy of compound econazole cream in the treatment of tinea corporis, tinea inguinalis, tinea manus, tinea pedis and its safety, Pharmaceutical care and research (Yaoxue Fuwu Yu Yanjin), Onychomycosis treated with itraconazole or griseofulvin alone with and without a topical antimycotic or keratolytic agent. GarciaBravo M, Kramer KJ, 34 AND 48 60. Additionally, patches of hard thickened skin occur on the soles, heels and side of the feet. DERMATOMYCOSES Butenafine used for 4 weeks versus placebo was evaluated (n = 80) in another trial (Tschen 1997), giving a statistically significant relative reduction in treatment failure of 81% (RR 0.19, 95% CI 0.08 to 0.43; Analysis 3.2). Gorsulowsky DC, et al. Comparison 6 Allylamines 12 weeks vs Azoles 12 weeks, Outcome 3 Medium term (6 weeks) treatment failure. Elewski B, Treatment of interdigital tinea pedis with 25% and 50% tea tree oil solution: A randomised placebocontrolled, blinded study, Treatment of chronic tinea pedis (athletes foot type) with topical terbinafine, Journal of American Academy of Dermatology. Take them to your local pharmacy which will dispose of them for you. A randomised trial of amorolfine 5% solution nail lacquer combined with oral terbinafine compared with terbinafine alone in the treatment of dermatophytic nail toenail onychomycosis. Hanifin JM, (b) the identity of study participants who were blind; Undecanoates The estimates of effectiveness of allylamines and azoles relative to placebo have conclusively demonstrated these drugs to be of greater effectiveness and we recommend that no more placebo controlled trials of allylamines or azoles should be conducted. Comparison 1 Allylamines vs Placebo, Outcome 3 Medium term (6 weeks) treatment failure.
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